adipose tissue inflammation and ectopic lipid accumulation in lungs

Adipose Tissue Distribution, Inflammation and Its ...- adipose tissue inflammation and ectopic lipid accumulation in lungs ,25/02/2020·Adipose tissue inflammation in obesity differs from typical inflammatory responses employed in host defense in that it is chronic, sterile, low grade, and affects the metabolic control of nutrient flow in adipose tissue, liver, muscle and pancreas, and has been termed “meta-inflammation.” One way it affects nutrient flow is by causing insulin resistance. There is good …inflammation; Molecular mechanism of obesity-induced ...mation, fibrosis, and ectopic lipid accumulation. Adipose Tissue Macrophages Metabolic syndrome is a common metabolic disorder that involves multiple organs and is associated with obe‐ sity and adipose tissue inflammation. It is considered that adipose tissue inflammation is mainly exacerbated by the interaction between enlarged adipocytes and macro‐ phages that …



Loss of periostin ameliorates adipose tissue inflammation ...

04/06/2018·In summary, we demonstrated that Postn has a critical role in HFD-induced adipose tissue inflammation and fibrosis, which may reduce lipid storage capacity and enhance ectopic lipid accumulation.

Epicardial adipose tissue in contemporary cardiology - PMC

Epicardial adipose tissue (EAT) can affect heart function in the setting of heart failure via inflammation, fibrosis and neural dysregulation as observed in coronary artery disease and atrial fibrillation. However, several specific mechanisms link EAT with heart failure. The EAT proteome can contribute to the pathogenesis of heart failure through the paracrine secretion of profibrotic …

Adipose Tissue - an overview | ScienceDirect Topics

Indeed, adipose tissue dysfunction, which is characterized by adipocyte hypertrophy, impaired lipid metabolism, inflammation, a disproportionate deposition of extracellular matrix components, and inadequate vascularization, seems to play a prominent role in insulin resistance and systemic low-grade inflammation. In this chapter, the metabolic and immunological consequences of …

The role of ectopic adipose tissue: benefit or deleterious ...

14/08/2020·The cellular structure and lipid/protein composition of adipose tissue surrounding chronically stimulated lymph nodes in rats. J Anat. 2003;202:551–61. J Anat. 2003;202:551–61.

Frontiers | Adipose Tissue Distribution, Inflammation and ...

25/02/2020·Hepatic lipid accumulation and inflammation. Several studies have reported an inverse relationship between hepatic lipid content and whole-body insulin sensitivity (291–293). The liver is a major target for the excessively produced inflammatory cytokines and FFAs released from obese WAT (see later). It has been estimated that nearly 60% of ectopic hepatic …

Adipose tissue dysfunction in obesity - PubMed

Ectopic fat accumulation including visceral obesity may be considered as a consequence of adipose tissue dysfunction, which is further characterized by changes in the cellular composition, increased lipid storage and impaired insulin sensitivity in adipocytes, and secretion of a proinflammatory, atherogenic, and diabetogenic adipokine pattern. This review focuses on the …

Introduction to Ectopic Fat

An overview of Ectopic Fat: fatty liver disease, white adipose tissue, Visceral Ectopic Fat,

Ectopic lipid accumulation: A potential cause for ...

Ectopic lipid accumulation is now known to be a mechanism that contributes to organ injury in the context of metabolic diseases. In muscle and liver, accumulation of lipids impairs insulin signaling. This hypothesis accounts for the mechanism of insulin resistance in obesity, type 2 diabetes, aging and lipodystrophy. Increasing data suggest that lipid accumulation in the …

Adipose tissue inflammation and ectopic lipid accumulation ...

Recent evidence suggests that reduced lipid storage in obese adipose tissue contributes to ectopic lipid accumulation in non-adipose tissues such as the liver, skeletal muscle, and pancreas, where lipotoxicity impairs their metabolic functions. Notably, chronic inflammation is capable of inducing insulin resistance, lipolysis, and interstitial fibrosis in adipose tissue, all of …

Molecular mechanism of obesity-induced adipose tissue ...

Molecular mechanism of obesity-induced adipose tissue inflammation; the role of Mincle in adipose tissue fibrosis and ectopic lipid accumulation. Miyako Tanaka. Author information Department of Immunometabolism, Nagoya University Graduate School of Medicine, Nagoya, Japan Keywords: Obesity, Adipose tissue inflammation, Adipose tissue fibrosis, …

Loss of periostin ameliorates adipose tissue inflammation ...

04/06/2018·In summary, we demonstrated that Postn has a critical role in HFD-induced adipose tissue inflammation and fibrosis, which may reduce lipid storage capacity and enhance ectopic lipid accumulation.

Lipid accumulation in non-adipose tissue and lipotoxicity

Importantly, obesity is not only associated with lipid accumulation in adipose tissue, but also in non-adipose tissues. The latter is also known as ectopic lipid accumulation and may be a … Lipid accumulation in non-adipose tissue and lipotoxicity Physiol Behav. 2008 May 23;94(2):231-41. doi: 10.1016/j.physbeh.2007.11.049. Epub 2007 Dec 5. Authors N A van …

Impaired Adipogenesis and Dysfunctional Adipose Tissue in ...

01/08/2018·Furthermore, the role of adipose tissue angiogenesis and inflammation for disease development will be reviewed. The final part of this review is focused on the consequences of a dysfunctional adipose tissue, reviewing the current knowledge on ectopic lipid accumulation, its effects in peripheral tissues, and the metabolic consequences.

RNA sequencing reveals perivascular adipose tissue ...

Excessive ectopic lipid accumulation leads to local inflammation and insulin resistance (IR). Indeed, overnutrition triggers uncontrolled inflammatory responses in WAT, leading to chronic low ...

Adipose tissue inflammation and ectopic lipid accumulation ...

Recent evidence suggests that reduced lipid storage in obese adipose tissue contributes to ectopic lipid accumulation in non-adipose tissues such as the liver, skeletal muscle, and pancreas, where lipotoxicity impairs their metabolic functions. Notably, chronic inflammation is capable of inducing insulin resistance, lipolysis, and interstitial fibrosis in adipose tissue, all of …

Adipose tissue inflammation and ectopic lipid accumulation.

Recent evidence suggests that reduced lipid storage in obese adipose tissue contributes to ectopic lipid accumulation in non-adipose tissues such as the liver, skeletal muscle, and pancreas, where lipotoxicity impairs their metabolic functions. Notably, chronic inflammation is capable of inducing insulin resistance, lipolysis, and interstitial fibrosis in adipose tissue, all of …

Loss of periostin ameliorates adipose tissue inflammation ...

04/06/2018·Introduction. A gradual and healthy expansion of adipose tissue in response to caloric intake is associated with appropriate vascular and extracellular matrix (ECM) remodeling 1.In contrast, increased adiposity is likely to involve a state of chronic inflammation in adipose tissue, thereby inducing systemic insulin resistance and ectopic lipid accumulation.

Impaired Adipogenesis and Dysfunctional Adipose Tissue in ...

01/08/2018·Furthermore, the role of adipose tissue angiogenesis and inflammation for disease development will be reviewed. The final part of this review is focused on the consequences of a dysfunctional adipose tissue, reviewing the current knowledge on ectopic lipid accumulation, its effects in peripheral tissues, and the metabolic consequences.

Adipose Tissue Immune Response: Novel Triggers and ...

21/03/2022·Adipose tissue inflammation mediates the association between excessive body fat accumulation and several chronic inflammatory diseases. A high prevalence of obesity-associated adipose tissue inflammation was observed not only in …

Epicardial adipose tissue in contemporary cardiology - PMC

Epicardial adipose tissue (EAT) can affect heart function in the setting of heart failure via inflammation, fibrosis and neural dysregulation as observed in coronary artery disease and atrial fibrillation. However, several specific mechanisms link EAT with heart failure. The EAT proteome can contribute to the pathogenesis of heart failure through the paracrine secretion of profibrotic …

Epicardial adipose tissue in contemporary cardiology - PMC

Epicardial adipose tissue (EAT) can affect heart function in the setting of heart failure via inflammation, fibrosis and neural dysregulation as observed in coronary artery disease and atrial fibrillation. However, several specific mechanisms link EAT with heart failure. The EAT proteome can contribute to the pathogenesis of heart failure through the paracrine secretion of profibrotic …

Adipose tissue inflammation and ectopic lipid …

Recent evidence suggests that reduced lipid storage in obese adipose tissue contributes to ectopic lipid accumulation in non-adipose tissues such as the liver, skeletal muscle, and pancreas, where ...

Adipose tissue inflammation and ectopic lipid accumulation ...

Recent evidence suggests that reduced lipid storage in obese adipose tissue contributes to ectopic lipid accumulation in non-adipose tissues such as the liver, skeletal muscle, and pancreas, where lipotoxicity impairs their metabolic functions. Notably, chronic inflammation is capable of inducing insulin resistance, lipolysis, and interstitial fibrosis in adipose tissue, all of …

The adipose tissue and lung health: like many things in ...

01/04/2020·Adipose tissue is not an inert organ but rather a systemic modulator of the response to environmental exposures and perhaps a potential target for therapeutic intervention <https://bit.ly/2UPRqqd> The adipose tissue and lung health: like many things in life, the extremes are not good | European Respiratory Society

Molecular mechanism of obesity-induced adipose tissue ...

Download Citation | Molecular mechanism of obesity-induced adipose tissue inflammation; the role of Mincle in adipose tissue fibrosis and ectopic lipid accumulation | …

Adipose Tissue, Inflammation and Atherosclerosis

Importantly, ectopic obesity, localized beyond the subcutaneous adipose tissue where there is increased local fat distributed in visceral, perivascular, and epicardial adipose tissue, seems to ...